http://dspace.lamu.edu.zm:8080/handle/123456789/102 Tue, 13 Oct 2026 05:27:24 GMT 2026-10-13T05:27:24Z http://dspace.lamu.edu.zm:8080/handle/123456789/236 Title: The Future of Scientific Leadership is Interdisciplinary: The 2019 CAS Future Leaders Share Their Vision Authors: Mili, Jovana V.; Ehnbom, Andreas; Garedew, Mahlet; Vincent-Ruz, Paulette; Schloemer, Tracy H.; Hodgson, Gregory K.; Oakley, Meagan S.; Sasaki, Koichi; Chander, Subhash; Le´ gare, Marc-Andre´; Callmann, Cassandra E.; Bismillah, Aisha N.; Van Osch, Dannie J.G.P.; Sanchez, Vanessa; Boase, Nathan R.B.; Mambwe, Dickson; Coley, Connor W.; Deng, Yuanxin; Betz, Kerry N.; Sanjose´-Orduna, Jesus; Natoli, Sean; Zhang, Liang; Bakulina, Olga; Fereyduni, Ehsan; Hilario-Martinez, Jazmin Ciciolil; Busta, Lucas; Hunter, Arianne; Park, Yoonsu; Zadeh, Farnaz Haidar Abstract: For the last decade, the CAS Future Leaders program has gathered early-career scientists from across the globe based on their outstanding accomplishments in the field of chemistry to provide support to participants in cultivating their own voices and futures in scientific leadership. The goal of the program has been to empower early-career scientists like us to begin to shape our own future leadership roles, from learning to convey effective speech by developing our own research stories to growing to be better mentors for the next generation of future leaders. In 2019, to honor the 10th anniversary of the program, the CAS Future Leaders program encompassed essential leadership skills divided into five topics, namely, storytelling, insights, strategies, perspectives, and impact, some of which were new to the program this year. However, what was not new to the program was an emphasis on the potential global impact that this program could make. To do this, the program brought together in this cohort 29 post-docs and graduate students, from 16 countries. A staple of this program is not only the breadth of countries that are represented but also the many facets of chemistry that are represented as demonstrated later in the article. One reason for this is that a leader in the sciences will need to be open to innovations across discipline and geographical boundaries, something that we explored a lot during our time together. Description: This publication can also be accessed through https://www.cell.com/iscience/pdf/S2589-0042(20)30634-9.pdf Tue, 01 Jan 2019 00:00:00 GMT http://dspace.lamu.edu.zm:8080/handle/123456789/236 2019-01-01T00:00:00Z http://dspace.lamu.edu.zm:8080/handle/123456789/235 Title: Innovation Experiences from Africa-Led Drug Discovery at the Holistic Drug Discovery and Development (H3D) Centre Authors: Singh, Vinayak; Mambwe, Dickson; Korkor, Constance Mawunyo; Chibale, Kelly Abstract: As the so-called “next frontier” in global economic terms, Africa’s disease burden continues to choke and cripple economic growth across the continent. The highest burden is attributable to malaria and tuberculosis (TB), which also remain among the deadliest infectious diseases affecting mankind the world over (Malaria, 627,000 deaths; TB, 1.5 million deaths, in 2020). In achieving self-determination with respect to the health needs of all who live on the continent, Africa must align with global north efforts and be a source of health innovation. This will in part require the creation of an ecosystem of innovative pharmaceutical R&D and expanding it across the continent by scaling up through sustained performance and excellence. To this end, the Holistic Drug Discovery and Development (H3D) Centre at University of Cape Town in South Africa has risen to this challenge. Here, we highlight the innovation experiences gained at H3D, covering the advances made in our quest to contribute to a global pipeline of therapeutic interventions against malaria and TB. We discuss selected chemical series starting from their identification, structure–activity relationships, mode of action, safety, proof-of-concept studies, and lessons learned. Description: This research article can be accessed through https://doi.org/10.1021/acsmedchemlett.2c00142 Sat, 01 Jan 2022 00:00:00 GMT http://dspace.lamu.edu.zm:8080/handle/123456789/235 2022-01-01T00:00:00Z http://dspace.lamu.edu.zm:8080/handle/123456789/234 Title: Structure–Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro Authors: Mambwe, Dickson; Kumar, Malkeet; Ferger, Richard; Taylor, Dale; Njoroge, Mathew; Coertzen, Dina; Reader, Janette; Van der Watt, Mariëtte; Birkholtz, Lyn-Marie; Chibale, Kelly Abstract: In the context of drug repositioning and expanding the existing structure–activity relationship around astemizole (AST), a new series of analogues were designed, synthesized, and evaluated for their antiplasmodium activity. Among 46 analogues tested, compounds 21, 30, and 33 displayed high activities against asexual blood stage parasites (PfNF54 IC50 = 0.025–0.043 μM), whereas amide compound 46 additionally showed activity against late-stage gametocytes (stage IV/V; PfLG IC50 = 0.6 ± 0.1 μM) and 860-fold higher selectivity over hERG (46, SI = 43) compared to AST. Several analogues displaying high solubility (Sol > 100 μM) and low cytoxicity in the Chinese hamster ovary (SI > 148) cell line have also been identified. Description: This article can also accessed through https://doi.org/10.1021/acsmedchemlett.1c00328 Fri, 01 Jan 2021 00:00:00 GMT http://dspace.lamu.edu.zm:8080/handle/123456789/234 2021-01-01T00:00:00Z http://dspace.lamu.edu.zm:8080/handle/123456789/233 Title: A Diverse View of Science to Catalyse Change Authors: Speight, Isaiah R.; Bojdys, Michael J.; Friščić, Tomislav; Stoddart, J. Fraser; Nelson, Toby L.; Mack, James; Robinson, Renã A. S.; Waddell, Emanuel A.; Lutkenhaus, Jodie L.; Godfrey, Murrell; Abboud, Martine I.; Aderinto, Stephen O.; Aderohunmu, Damilola; Bibič, Lučka; Borges, João; Dong, Vy M.; Ferrins, Lori; Fung, Fun Man; John, Torsten; Lim, Felicia P. L.; Masters, Sarah L.; Mambwe, Dickson; Thordarson, Pall; Titirici, Maria-Magdalena; Tormet-González, Gabriela D.; Unterlass, Miriam M.; Wadle, Austin; Yam, Vivian W.-W.; Yang, Ying-Wei Abstract: Valuing diversity leads to scientific excellence, the progress of science and most importantly, it is simply the right thing to do. We can value diversity not only in words, but also in actions. From the structure of DNA,1 to computer science2 and space-station batteries,3 several key scientific discoveries that enhance our lives today were made by marginalized scientists. These three scientists, Rosalind E. Franklin, Alan M. Turing and Olga D. Gonzalez-Sanabria, did not conform to the ́ cultural expectations of how scientists should look and behave. Unfortunately, marginalized scientists are often viewed as just a resource rather than the lifeblood that constitutes science itself. We need to embrace scientists from all walks of life and corners of the globe; this will also mean that nobody is excluded from tackling the life-threatening societal challenges that lie ahead. An awareness of science policy is essential to safeguarding our future. Science policy deals with creating the framework and codes of conduct that determine how science can best serve society.4−6 Discussions around science policy are often accompanied by anecdotes of ‘good’ and ‘bad’ practices regarding the merits of diversity and inclusion. Excellence and truth, which flow inexorably from diversity and inclusion, are the bedrocks upon which science should influence political and economic outcomes. A vital area of science policy is to support the professional development of marginalized scientists, an objective that must be acted upon by scientific leaders and communicators. Description: This research can be accesssed through https://doi.org/10.1021/jacs.0c07877. Wed, 01 Jan 2020 00:00:00 GMT http://dspace.lamu.edu.zm:8080/handle/123456789/233 2020-01-01T00:00:00Z